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The Sixth International Workshop on Seizure Prediction was a forum that brought together an international interdisciplinary group involving epileptologists, engineers, physicists, mathematicians, neurosurgeons and neuroscientists focused on the development of treatments for epilepsy especially based on closed loop prediction and interventions.  The focus was to better understand the underlying physiological mechanisms as they specifically relate to clinical recordings.  At a fundamental level, the goal of seizure prediction is to identify the underlying mechanisms of seizure generation and to engineer systems that will detect those dynamics and provide for intervention.

This meeting focused attention on basic questions at the intersection of engineering, computational and epilepsy neuroscience necessary for predicting and intervening with seizures:  how seizures arise in the neocortex, how to identify sites of seizure origination, how seizures spread, and how they terminate.  We have identified these topics as key roadblocks to further advances in treatment of pharmacoresistant epilepsy syndromes. Through these questions we were able to focus attention on bridging clinical and physiological metrics to arrive at new approaches to understand epileptic seizure generation mechanisms across all scales of brain from neuron to organism, and especially close the loop between models of seizure generation and physiological observations.